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Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Palbociclib Regimen Yields 'Incredible' PFS Gain in Metastatic Breast Cancer

Study results are "historic," expert says

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Risk-Reducing Surgery May Benefit BRCA Carriers With Early-Onset Breast Cancer

Lower rates of mortality and cancer recurrence with mastectomy, salpingo-oophorectomy

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Skip Surgery for DCIS in Favor of Active Monitoring?

No invasive cancer increase at 2 years, but editorialists say data don't back active monitoring

A computer rendering of a heart and pulse.

Lung Cancer Drug Osimertinib Tied to Cardiac Events, Even in Low-Risk Patients

Signal largely driven by newly emerging arrhythmias

A photo of a male physician showing his male patient a tablet.

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Subcutaneous Cancer Immunotherapies Provide New Options for Physicians and Patients

ASH over a photo of San Diego Convention Center

Pulled Myeloma Drug Improves Survival in Trial

DREAMM-7 findings help pave the way for Blenrep's return

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Oral SERD Impresses in Advanced Breast Cancer With ESR1 Mutations

However, imlunestrant failed to improve PFS among entire trial population

ASH over a photo of San Diego Convention Center

One CAR T-Cell Therapy for Multiple Myeloma Tops Another in Propensity Matched Study

Higher response rate, PFS, OS with cilta-cel, but ide-cel had lower rate of severe toxicity

ASHP over a photo of Ernest N. Morial Convention Center in New Orleans, LA.

Cancer Patients Who Completed Medication Survey Received More Help From Pharmacists

Study assessed pharmacist interventions for adverse events

ASH over a photo of San Diego Convention Center

Pirtobrutinib Delays Progression in CLL Already Treated With a BTK Inhibitor

But no overall survival benefit seen in confirmatory trial

ASH over a photo of San Diego Convention Center

Tafasitamab-Based Combination Boosts PFS in Relapsed/Refractory Follicular Lymphoma

Benefit seen in all prespecified subgroups, including high-risk patients

A photo of a female gynecologist putting a cervical brush into a sample container with a female patient in the background.

USPSTF Plans Changes to Cervical Cancer Screening Recommendations

Self-collected HPV testing is a new addition

A photo of a nurse holding a bag of red blood cells.

Generous Blood Transfusions Not Beneficial for Some With Burst Brain Aneurysms

SAHARA rounds out this year's notable trials on blood transfusions in critically ill patients

ASH over a photo of San Diego Convention Center

Benefits of Transplant for Pediatric Sickle Cell Disease Add Up a Decade Later

Better disease outcomes, measures of cognition, and quality-of-life vs standard care, study finds

ASH over a photo of San Diego Convention Center

Transplantation Fails to Improve Survival in Mantle Cell Lymphoma

New standard of care for patients in first remission?

ASH over a photo of San Diego Convention Center

Lentiviral Gene Therapy Shows Promise in Severe Hemophilia A

Increased factor VIII levels to mild or moderate range, with annualized bleeding rate of zero

2024 YEAR IN REVIEW CLL over a computer rendering of CAR T cell therapy in chronic lymphocytic leukemia.

Year in Review: Chronic Lymphocytic Leukemia

Top news in 2024 included the first CAR-T approval for CLL, triplet regimens, and more

A photo of a female physician at her desk talking to her male patient.

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Alecensa (alectinib) Offers Hope for Certain Patients With ALK Positive NSCLC

ASH over a photo of San Diego Convention Center

Hydroxyurea Shows Some Benefits in Milder Sickle Cell Disease

Treatment tied to fewer vaso-occlusive pain events, hospitalizations versus placebo

ASH over a photo of San Diego Convention Center

Fixed-Duration Oral Doublet for Fit CLL Wins in Frontline Setting

AMPLIFY trial paves the way for FDA approval of acalabrutinib plus venetoclax

ASH over a photo of San Diego Convention Center

Treatment of Smoldering Myeloma Cuts Progression Rate in Half

Daratumumab significantly improved PFS, OS, but identity of high-risk population remains elusive

ASH over a photo of San Diego Convention Center

Promising Results With Epcoritamab Monotherapy in Relapsed/Refractory CLL

Complete responses seen in 43% of patients in expansion cohort of EPCORE CLL-1 study

ASH over a photo of San Diego Convention Center

Novel BTK Inhibitor Succeeds in Heavily Pretreated Immune Thrombocytopenia

Rilzabrutinib specifically designed to reduce platelet-targeting autoantibodies

ASH over a photo of San Diego Convention Center

Loncastuximab-Rituximab Boosts Response Rates in R/R Follicular Lymphoma

Two-thirds of phase II patients had a complete response at 12 weeks of treatment

ASH over a photo of San Diego Convention Center

Dietary Intervention Shows Promise in Blood Cancers

High-fiber diets tied to improved outcomes in stem-cell transplants, slowing myeloma precursors

Texting to Improve Adherence to CVD Medications; Detecting Maternal Cancers

Also in TTHealthWatch: U.S. drug prices under Medicare's price negotiation system

ASH over a photo of the San Diego Convention Center

Dual Targeted CAR-T Yields 99% Response Rate in Pediatric ALL

Cytokine release syndrome developed in all patients, including grade 3/4 events in nearly half

ASH over a photo of San Diego Convention Center

New Standard for Newly Diagnosed Pediatric B-Cell Acute Lymphoblastic Leukemia

Blinatumomab consolidation reduced risk of relapse by 61% versus chemotherapy alone

ASH over a photo of San Diego Convention Center

Eltrombopag Improves Outcomes in Kids With Newly Diagnosed ITP

Drug may potentially "transform" approach to upfront treatment, investigator says

A screenshot of Senator Jeff Merkley speaking during this hearing.

Experts Wrestle Over Uses of PFAS During Senate Hearing

Industry witness warns of unintended consequences of blanket bans

RSNA over a photo of McCormick Place in Chicago, IL.

Self-Pay, AI-Enhanced Breast Cancer Screening Detected More Cancers

Overall cancer detection rate was about 43% higher versus women who chose not to participate

Onco Break over a computer rendering of a cancer cell.

AI Breath Test IDs Cancers; More Grief for Prior Auth; Imatinib Discoverer Resigns

News, features, and commentary about cancer-related issues

A photo of a stethoscope in the center of a circle of variously colored cancer ribbons.

Nearly 6 Million Deaths From Five Major Cancer Types Averted Since 1975

Prevention and screening efforts accounted for 80% of those averted deaths

FDA APPROVED durvalumab (Imfinzi) over a computer rendering of lung cancer.

Durvalumab Wins FDA Approval in Limited-Stage SCLC

Unprecedented 22.5-month improvement in median overall survival as consolidation therapy

FDA APPROVED zenocutuzumab-zbco (Bizengri) over a computer rendering of monoclonal antibodies attacking cancer cells.

FDA OKs First Drug Targeting NRG1 Gene Fusion in Pancreatic, Lung Cancers

Zenocutuzumab achieved response rates of 40% in pancreatic adenocarcinoma, 33% in advanced NSCLC

A computer rendering of cell free nucleic acids in the blood.

Prenatal Cell-Free DNA Sequencing May Help Detect Cancer in Mothers

Nearly half of women with unusual or nonreportable cfDNA-sequencing results had cancer

A computer rendering of a transparent female body with a fatty liver highlighted.

Serious Outcomes of Steatotic Liver Disease Hit Men and Women Differently

Liver cancer risk higher among men, while cirrhosis more common in women

A computer rendering of sickle cells in the blood flow.

Makers of Sickle Cell Disease Gene Therapy to Participate in Payment Model, CMS Says

Outcomes-based model designed to improve access to pricey treatments

A photo of a technician putting a human brain into a container of formaldehyde.

Formaldehyde Causes More Cancer Than Any Other Toxic Air Pollutant

Little is being done to curb the risk

A computer rendering of a transparent body with a tumor in the lungs highlighted.

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What Could This Exploratory 5-Year Survival Data in Adjuvant NSCLC Treatment Mean?

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