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Lupus

News, opinions and meeting coverage in rheumatology.

A photo of a man鈥檚 hand inflamed by systemic lupus erythematosus

Could Two Targeted Therapies Be Better Than One in Lupus?

Mid-stage trial tests a JAK inhibitor as monotherapy and in combination with a BTK blocker

A photo of a prescription bottle of metformin tablets next to a glucose monitor.

Lupus Complications Reduced With Common Diabetes Drug

Metformin benefits seen extending way beyond its glucose-lowering properties

EULAR over a photo of Vienna Exhibition Center in Vienna, Austria.

CAR-T Treatment Continues to Astonish in Rheumatologic Diseases

Numbers of patients, length of follow-up keep growing with no visible downside (yet)

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Star Singer's Illness; AI Imitating the Dead; Internet-Addicted Brains

Health news and commentary gathered by 名媛直播 staff

A photo of a bottle of hydroxychloroquine tablets.

Retinopathy With Long-Term HCQ Use: Large Study IDs Risk Factors

Hint: it's not just the cumulative dose

A photo of a pregnant woman holding a blisterpack of tablets.

Rare Pregnancy Problem Linked to Thiopurines, FDA Says

Agency finds risk for intrahepatic cholestasis of pregnancy mostly in IBD, lupus patients

A close up photo of the hand of a person with systemic lupus erythematosus

Can Innate Immune System Be Targeted Directly in Lupus?

Japanese researchers open new front in SLE therapy

A photo of a little girl and her mother approaching a male physician at his desk.

Unexplained Rash With No Itch and Shoulder Pain Suddenly Affects Young Girl

Skin symptoms dramatically improved after use of sun protection

A photo of a man sitting on a couch, holding a tissue, and pressing his hand to his nose.

Sinusitis Tied to Later Autoimmune Disease

Olmsted County analysis points to substantial risk

A computer rendering of an antibody and strands of RNA

Novel Lupus Approach Yields Mixed Results in Early Trial

Hints of benefit seen in patients with more active disease

A computer rendering of X and Y chromosomes.

A Clue on Why Lupus, Other Autoimmune Diseases Strike Far More Women Than Men

New research shows that the extra X chromosome is involved, but in an unexpected way

A photo of a bottle of mycophenolate mofetil tablets.

Yes, Lupus Patients Can Stop MMF Treatment

Randomized trial shows non-inferiority to maintenance ... with caveats

Using Baseline Markers to Predict Response in Psoriatic Arthritis

More biomarker research is needed, but new study is a good start

ACR over a photo of the San Diego Convention Center in San Diego, California

CAR T-Cell Approach to Autoimmune Disease Gains Traction

Worries about vaccine responsiveness relieved; Big Pharma gets interested

ACR over a photo of the San Diego Convention Center in San Diego, California

Pregnant Patients With High Autoantibody Levels Need Fetal Heart Monitoring

Study should help target frequent testing to those most likely to benefit

ACR over a photo of the San Diego Convention Center in San Diego, California

B-Cell Depletion Helps Maintain Kidney Function in Lupus Nephritis

Secondary trial analysis boosts case for Gazyva

A photo of test tubes labeled: lupus anticoagulant and lupus centrifuge

Major Source of Lupus Morbidity More Common in Certain Racial-Ethnic Groups

Good news is that it's not common overall

A close up photo of a bottle of hydroxychloroquine tablets

Rheum Patients on HCQ: Stick With It or Face Heart Consequences

Population-based study links adherence with risk for cardiovascular events

A computer rendering of intestinal microflora

Gut Microbiome Instability Associated With Lupus Nephritis Flares

One specific gut microbe may be a major factor

EULAR over a photo of the MiCo Convention Center in Milan, Italy.

More Success for CAR T-Cell Therapy in Rheumatic Disease

Stunning improvement for two patients with rare form of autoimmune myositis

A photo of the vial and packaging of Saphnelo over a photo of a woman鈥檚 face with discoid lupus erythematosus

New Lupus Drug Cuts Skin Disease When Other Agents Fail

Small study backs anifrolumab for salvage therapy

A portrait of a senior woman with a butterfly rash on her cheeks.

Older Lupus Patients Need Follow-Up After Hospital Discharge ... or Else

Medicare data show what happens when it's neglected

A close up of a male nurse giving a male patient a covid vaccination

Study: Diminished COVID Vaccine Response in Lupus

Immunosuppressants seem responsible; mycophenolate "holiday" may help

An elderly patient is cared for by an older caregiver.

Caregivers Face Increased Arthritis Burden

Question remains: why?

A computer rendering of a chimeric antigen receptor spanning the cell membrane of a T-cell

Is Cancer Therapy Also a Lupus Cure?

Patients in pilot study show months-long complete remission

A photo of a Black woman sitting on the edge of her bed with her hand on her head.

Low Sleep Tied to Lupus Risk

But which way does causal arrow point?

A computer rendering of antibodies.

Mixed Results for Novel Lupus Drug in Mid-Stage Trial

Developer of litifilimab, an anti-BDCA2 antibody, presses ahead despite phase II hiccups

A photo of a mature Black woman lying in a hospital bed.

Organ Damage in Lupus: Some Ethnicities Bear More Burden Than Others

Results from California cohort mirror epidemiology of lupus itself

A computer rendered monoclonal antibody over a photo of a lupus erythematosus rash on a man鈥檚 abdomen.

BDCA2-Targeting Antibody May Be Effective for Cutaneous Lupus

In small randomized trial, litifilimab shows superiority over placebo for skin disease activity

An overhead shot of a large racially diverse group of people holding small U.S. flags and looking up at the cameraperson.

U.S. Should Expect More Lupus Cases as Racial-Ethnic Diversity Grows

Study finds doubled rates over 40-plus years in this bellwether county

A photo of a man鈥檚 hand against the sky blocking the sun.

Does Sunlight Trigger Lupus?

Analysis of data from major study suggests "yes," but falls short of clear conclusion

A close up of a knee replacement scar on a man standing with crutches.

Guideline: Timing Is Everything for RA and Lupus Patients Needing Joint Replacement

New advice on which antirheumatic meds to continue and which to stop before surgery

A computer rendered DNA helix behind a photo of a box of Imuran Azathioprine tablets.

Genotype Tied to Azathioprine Discontinuation for Toxicity

Nearly threefold risk seen with a genotype most common among Black patients

EULAR over a photo of the Bella Center Copenhagen in Denmark

TYK2 Inhibitor Shows Promise in Lupus

Latest indication for deucravacitinib seen as approvable for multiple rheumatologic conditions

A computer rendering of the layers of the epidermis with Keratinocytes labeled.

In Lupus, 'Normal-Appearing' Skin Is Not Normal

Groundwork for inflammation laid before lesions develop

A photo of the packaging and blister pack of Prograf.

Tacrolimus Measures Up in Lupus Nephritis Trial

Oral alternative to IV drugs

A white pill laying in the hand of a person affected by systemic lupus erythematosus

Mixed Results for Oral Lupus Drug in Phase II

Mid-stage study offers hope but also reason for caution

A portrait of a young Black woman wearing a protective mask lying in a hospital bed.

Acute Muscle Weakness and Skin Rash Following a Lupus Diagnosis

Clinicians consider many differentials

A close up of a bottle of hydroxychloroquine tablets in a persons hand.

Hydroxychloroquine Linked to Less Heart Risk in RA, Lupus

Current use of the antimalarial especially was particularly associated with less thrombosis

ACR over a photo of the Moscone Center in San Francisco, CA.

Voclosporin Benefits in Nephritis Persist at 30 Months

No new safety signals seen in long-term extension for lupus nephritis

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