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General Hepatology

News, opinions and meeting coverage in gastroenterology.

A photo of a man holding a semaglutide injection pen.

GLP-1 Drugs Could Help People With Alcohol Use Disorder

Real-world data suggested semaglutide, liraglutide reduced AUD-related hospitalizations

A photo of bottles of Ocaliva tablets over a computer rendering of the gallbladder with bile duct and biliary tree.

FDA Rejects Full Approval of Liver Disease Drug

Agency's decision on obeticholic acid in PBC follows negative advisory committee meeting

ACG over a photo of Pennsylvania Convention Center in Philadelphia, PA.

Rifaximin Reduced Overt Hepatic Encephalopathy Recurrence Over Lactulose

Rifaximin also reduced mortality, but its high cost may be a barrier

A computer rendering of a transparent body with a diseased liver highlighted.

Algorithm May Be Able to Predict HCC Risk in Advanced Chronic Liver Disease

Easy to apply, uses parameters commonly measured in outpatient and inpatient settings

Rainfall and Mortality; Identifying Risk for Preeclampsia

Also in TTHealthWatch: HIV-positive kidney donors

A computer rendering of a diseased liver in a transparent body.

Novel Drug Effective Against MASH in Phase II Trial

Fatty acid synthase inhibitor targets main drivers of liver injury

A photo of a female doctor writing on a clipboard.

Industry Clinic 鈥� Ad Insights

Why Are Liver Disease Patients Being Left Behind?

A close up photo of an injection pen.

GLP-1 Drugs in MASLD Tied to Lower Risk of Cirrhosis, Death

Limited benefit seen in patients with established cirrhosis, however

ESMO over a photo of Fira Barcelona Gran Via in Barcelona, Spain.

Another Possible Treatment Option for Intermediate-Stage Liver Cancer

Adding lenvatinib, pembrolizumab to TACE significantly improved PFS, numerically improved OS

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

Approved Liver Disease Drug Has No Clinical Benefit, FDA Panel Says

Agency advisors put their foot down on shaky science for Ocaliva in primary biliary cholangitis

FDA WARNING fezolinetant (Veozah) over a photo of Veozah tablet, bottle and packaging.

FDA Warning on Hot Flash Drug

Clinicians should perform liver blood tests before and during Veozah treatment

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

FDA Reviewers Skeptical of Ocaliva for Rare Bile Duct Disease

Agency advisory panel to examine complicated efficacy data and liver safety concerns

A photo of surgeons performing a liver transplant.

Women With HCC Less Likely to Receive Liver Transplant, More Likely to Die Than Men

This difference is mostly explained by their smaller stature, researchers say

A computer rendering of a transparent body with the liver highlighted in red.

Rate of Mortality After ED Discharge for Cirrhosis Doubles That of Heart Failure

Patients who lacked a follow-up visit may be at particularly high risk for death

Amino Acids May Protect Kidneys During Surgery; EDTA for Chelation Therapy

Also in TTHealthWatch: suicidality among spouses of people with cancer

A photo of a female nurse holding a bag of blood for transfusion.

No Effect of Tranexamic Acid on Bleeding in Surgery for Liver Cancer

No difference from placebo in transfusion rate, blood loss, with higher complication rate

FDA APPROVED seladelpar (Livdelzi) over a rendering of a transparent body with the gallbladder and bile duct highlighted.

FDA OKs New Option for Primary Biliary Cholangitis

Seladelpar improved biochemical response, ALP normalization versus placebo in phase III trial

A photo of a spilled bottle of turmeric, ginger, and black pepper supplements

Millions of Americans Use Potentially Hepatotoxic Botanical Products

And liver injuries tied to herbal and dietary supplements are on the rise, data show

A close up photo of bottles of Eliquis tablets.

Which Anticoagulant Is Safest for Afib Patients With Cirrhosis?

National cohort study finds up to 47% fewer serious hemorrhagic events with one agent

Aspirin Overuse; Biotypes of Depression and Anxiety

Also in TTHealthWatch: medications and the liver, and managing gestational diabetes

FDA MARKETING Hepatitis C RNA Test (Xpert HCV test + GeneXpert Xpress System) over a photo of the devices.

FDA OKs First Point-of-Care Test for Detecting Hep C in At-Risk Adults

Results as quick as 1 hour, enabling a test-and-treat approach

A computer rendering of a liver under a red umbrella.

Real-World Analysis Identifies Meds Tied to Higher Risk of Liver Injury

Case reports may not be as reliable, researchers say

ADA over a photo of Orange County Convention Center in Orlando, FL

Novel GLP-1/Glucagon Drug Promising for Weight Loss

Phase II data support testing pemvidutide for comorbid obesity and liver conditions

A photo of the vials and packaging of Irinotecan hydrochloride.

Nanoliposomal Irinotecan Fails to Boost Survival in Treated Advanced Biliary Cancer

No difference in PFS, median OS favored control group

EASL over a photo of Milano Convention Centre in Milan, Italy

Testosterone Prodrug Improves Muscle Mass, Encephalopathy in Men With Cirrhosis

Androgen precursor may help cirrhosis-related sarcopenia

EASL over a photo of Milano Convention Centre in Milan, Italy

Rifaximin Prophylaxis Fails for Bacterial Peritonitis in Cirrhotic Patients

"Is it time to say primary prophylaxis is dead?" one expert asks

FDA APPROVED oral elafibranor (Iqirvo) over a computer rendering of a diseased liver.

Novel Drug for Rare Chronic Liver Disease Wins Conditional FDA Approval

First-in-class PPAR agonist led to biochemical responses in more than 50% of patients in trial

EASL over a photo of Milano Convention Centre in Milan, Italy

Patients With Severe ACLF on Liver Transplant Waitlists Face High Mortality Rates

Urgent need for organ allocation system reform, researchers say

EASL over a photo of Milano Convention Centre in Milan, Italy

Weight Loss/Diabetes Drug Has Positive Treatment Effect on MASH

GLP-1/GIP agonist also improved fibrosis biomarkers, liver fat, and stiffness in phase II trial

EASL over a photo of Milano Convention Centre in Milan, Italy

Novel Glucagon/GLP-1 Receptor Dual Agonist Improved MASH in Phase II Study

Effects may be related to weight loss, not changes in fibrogenesis, expert suggests

EASL over a photo of Milano Convention Centre in Milan, Italy.

Novel Intelligent Liver Function Test Platform Improves Liver Disease Diagnosis

iLFT is now an essential, highly utilized tool at one U.K. primary care system

EASL over a photo of Milano Convention Centre in Milan, Italy.

Bulevirtide/Pegylated Interferon Combo Beats Monotherapy for Chronic Hepatitis D

Combo therapies for HDV with drugs other than pegylated interferon would be better, expert says

A photo of surgeons performing a liver transplant.

Changes to Liver Transplant Policy Increased Costs in Vulnerable Areas

Hospital costs increased 12% in low-income areas vs 5.1% in high-income areas

FDA WITHDRAWN infigratinib (Truseltiq) over a photo of a box of Truseltiq capsules.

FDA Withdraws Approval of FGFR Inhibitor for Bile Duct Cancer

Sponsor for infigratinib (Truseltiq) failed to recruit and enroll patients in confirmatory study

A computer rendering of liver cancer.

Resection for Early Liver Cancer Tied to Improved Survival

5-year OS rate nearly doubled vs nonsurgical approaches for early HCC, retrospective study finds

AACE over a photo of the Hyatt Regency New Orleans in New Orleans, LA

Liver Disease, High Lipoprotein(a) Tied to Higher MI Risk in Diabetes Patients

Sixfold increased risk of non-fatal MI among patients with highest levels of Lp(a)

A close up shot of a glass of red wine with an out of focus bottle in the background.

Are Health Workers More Prone to Alcohol-Related Death?

No, and physicians appear to have the lowest risk

A photo of a pregnant woman holding a blisterpack of tablets.

Rare Pregnancy Problem Linked to Thiopurines, FDA Says

Agency finds risk for intrahepatic cholestasis of pregnancy mostly in IBD, lupus patients

A CT scan showing an abnormal mass in the liver.

Liver Cancer Screening Benefits Patients With Cirrhosis, Study Suggests

Analysis still finds improved survival after correcting for lead- and length-time biases

A photo of Environmental Protection Agency Administrator Michael Regan speaking at event at Howard University, in Washington.

EPA Bans Consumer Use of Toxic Chemical Known to Cause Liver, Lung Cancers

Methylene chloride has killed at least 88 workers since 1980

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