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Alzheimer's Disease

News, opinions and meeting coverage in geriatrics.

FDA APPROVED brexpiprazole (Rexulti) over a photo of a agitated-looking senior woman.

FDA OKs First Drug for Agitation in Alzheimer's Dementia

Boxed warning on increased mortality risk in elderly patients remains for brexpiprazole

A photo of a senior woman touching the digital bracelet on her wrist.

AI Offers Hope for Those With Alzheimer's Disease

How tech can help make a better future for patients

A photo of a mature woman sitting on the edge of her bed in a dark room.

Alzheimer's Proteins Reduced by Sleep Drug

Both amyloid and tau levels fell in early trial

A photo of a senior man performing a memory test while sitting across a desk from a male physician.

Test Predicts Transition From Normal to Impaired Cognition

Sensitive, simple test detects subtle deficit at its earliest stage

A photo of a male cardiac surgeon performing catheter ablation on a patient with atrial fibrillation

RF Ablation or Drugs for Afib: Choice May Matter for Cognitive Outcomes

New study suggests one does a better job of protecting the brain

FDA ADCOMM brexpiprazole (Rexulti) over a photo of an agitated senior woman rising her index finger.

FDA Advisors Endorse Rexulti for Agitation in Alzheimer's Dementia

Increased mortality risk seen but benefits may outweigh this, panelists say

FDA ADCOMM brexpiprazole (Rexulti) over a photo of an agitated senior woman rising her index finger.

Rexulti Works for Agitation in Alzheimer's, Despite Risks, Says FDA Staff

Increased mortality risk consistent with other antipsychotics in elderly dementia patients

A computer rendering of of amyloid plaques affecting neurons and neurofibrillary tangles inside neurons

Brains Shrink With Anti-Amyloid Alzheimer's Drugs

Treatments accelerate brain atrophy, but reasons why remain a mystery

A photo of a kale salad with herbs, pomegranate, and persimmon

Autopsies Show Relationship Between Alzheimer's Pathology and Diet in Older Adults

Green leafy vegetable intake inversely correlated with pathology in postmortem brain tissue

A photo of a dissected brain affected by Alzheimer's disease.

We May Be Better at Fending Off Dementia, Autopsies Suggest

Neurodegeneration pathologies look similar across birth epochs as dementia incidence declines

A photo of a young physician talking to his senior male patient in his office.

There's No 'Recipe' to Reduce Dementia Risk -- Yet

Until more evidence emerges, here's how to discuss it with patients

A computer rendering of amyloid plaques on a neuron.

Blood Test Predicts Which People With Amyloid Are Likely to Decline Cognitively

Plasma p-tau217 outperformed other preclinical Alzheimer's measures

A computer rendering of amyloid plaques forming on a motor neuron.

Their Alzheimer's Disease Didn't Worsen. Why?

Case reports find one healthy habit in common

A computer rendering of viral encephalitis

Viruses Tied to Subsequent Dementia, Other Neurodegenerative Diseases

Viral encephalitis and Alzheimer's disease showed strongest links

A photo of two senior couples talking after exercise in a park.

Memory Decline Tied to Lifestyle Factors

Healthy lifestyle slowed memory loss, even in APOE4 carriers

A microscope image of glial fibrillary acid protein astrocytes

Alzheimer's Disease Detected in Blood a Decade Before Clinical Symptoms

GFAP levels change before tau, neurodegeneration biomarkers

FDA APPROVED Lecanemab-irmb (Leqembi) over a computer rendering of amyloid plaques forming between neurons

Alzheimer's Drug Lecanemab Wins FDA Approval

Anti-amyloid showed modest benefit in phase III trial, but was linked to adverse events

A photo of a mature woman wearing headphones during a hearing test in a sound proof booth.

Earlier Health Conditions Tied to Subsequent Dementia

Alzheimer's disease, vascular dementia links are time-dependent

A computer rendering of a person鈥檚 transparent head with a cerebral hemorrhage highlighted

Scattered Brain Bleeds, Vasculitis in Alzheimer's Trial Death

Case report is published days ahead of FDA lecanemab decision

A computer rendering of aggregations of tau proteins causing disintegration of a microtubule

Novel Blood Test Detects Alzheimer's Neurodegeneration

Brain-derived tau distinguished Alzheimer's from other dementias

A photo of a mature man using two mirrors to see his bald spot.

5-ARIs Not Linked to Risk of Dementia Over the Long Term

However, finasteride and dutasteride were associated with an increased risk of depression

A computer rendering of the molecular model of calcifediol over a human brain.

Brain Vitamin D Tied to Cognitive Function

No links seen with Alzheimer's or dementia pathology, however

A photo of a mature, bearded man wearing a cochlear implant

Use It, or Lose It: Hearing Aids Linked to Cognitive Benefit

Treating hearing loss makes a difference, meta-analysis suggests

A photo of Chris Hemsworth

Chris Hemsworth's APOE4 Alzheimer's Gene

The Thor actor recently learned about his genetic predisposition

A computer rendering of nerve cells affected by Alzheimer鈥檚 disease.

Second Trial Participant Dies in Alzheimer's Drug Study

"All eyes are on lecanemab," a closely watched anti-amyloid treatment

A photo of a mature man struggling to remember something.

Dementia Signs Emerge Up to 9 Years Before Diagnoses

Cognitive, functional changes spotted in pre-Alzheimer's patients and others

A photo of a mature couple chopping vegetables in the kitchen.

Does Diet Matter? Study Questions Links Between Diet and Dementia

Diet combined with other risk-reduction strategies may show different results

AAO over a photo of McCormick Place in Chicago, Illinois

AAO Roundup: Glaucoma Subtype Linked to Alzheimer's Disease Risk

Other studies report fewer reoperations with combo eye surgery and vision risk with shingles

A photo of the packaging and blisterpacks of Cialis and Viagra over a computer rendering of amyloid plaques.

Can Erectile Dysfunction Drugs Reduce Dementia Risk?

DREAM study findings conflict with other recent data

A photo of a worried looking mature man with his head in his hands.

Dementia Diagnosis Linked to Suicide

Risk almost seven times higher for people with diagnosis before age 65

Psych Congress over a photo of the Ernest N. Morial Convention Center in New Orleans, Louisiana

Rexulti Calms Alzheimer's Dementia-Related Agitation

But atypical antipsychotic disappoints in borderline personality disorder

A photo of a man with down syndrome working in a factory.

Hormone Treatment Improves Cognition in Down Syndrome

Pulsatile GnRH therapy boosted brain connectivity in pilot study

A computer rendering of a herpes virus.

Herpes Viruses Linked to Brain Changes

But no evidence of a relationship between herpes and Alzheimer's disease

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Researchers Delve Into Data From Failed Crenezumab Trial

Anti-amyloid agent missed primary endpoints, though small numeric differences favored the drug

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Blood Tests: Not Ready for Primary Care

But some biomarkers may revolutionize Alzheimer's diagnosis in the future

AAIC over a photo of the San Diego Convention Center in California.

Racism Experiences Tied to Worse Cognition

Links between racism and memory seen in both midlife and old age

AAIC over a photo of the San Diego Convention Center in California.

ICU Stay Doubles Dementia Risk

Higher risks of both Alzheimer's and all-type dementia seen

AAIC over a photo of the San Diego Convention Center in California.

Biomarkers Show Who Faces Near-Term Cognitive Decline

Consistent findings emerge in four groups of cognitively normal adults

A photo of an Asian man holding up a piece of deep fried chicken.

Dementia Risk Climbs With Intake of Ultra-Processed Foods

Swapping out ultra-processed for unprocessed or minimally processed foods can lower risk sharply

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Doctored Images, Fake Data, Plagiarism: Scandals Rock Alzheimer's, Cancer Research

This past week in healthcare investigations

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